Defending champion Naomi Osaka will seek a spot in the U.S. Open quarter-finals when she returns to the court on Monday while second seed Rafa Nadal faces former winner Marin Cilic in last 16 action.
Osaka, who brought 15-year-old American Coco Gauff’s New York run to an end in the third round, will kick off the day session inside Arthur Ashe Stadium when she faces Swiss 13th seed Belinda Bencic.
The Japanese 21-year-old has had an up-and-down year since her Australian Open win and she has her hands full against a rested Bencic, who enjoyed a walkover into the last 16.
Bencic will bring plenty of confidence given she beat Osaka in their two meetings this year to improve to 2-1 in their head-to-head record.
Nadal, who retired injured from last year’s New York semi-final with knee trouble, kicks off the evening session inside Ashe and will be rested and raring to go against the 2014 champion Cilic after smooth passage to the last 16.
The 18-times Grand Slam champion has not dropped a set and had a walkover in the second round when Australian Thanasi Kokkinakis withdrew with injury.
But the Spaniard knows he faces a tough test against the big-serving Croat.
In other action, German sixth seed Alexander Zverev will face Argentine Diego Schwartzman while Russian Andrey Rublev, who upended Nick Kyrgios in the third round, meets Italian Matteo Berrettini.
Canadian teenager Bianca Andreescu will close out proceedings under the Arthur Ashe lights when she battles American qualifier Taylor Townsend, who has found success with a throwback game of aggressive net play.